The Impact of Pathological Ventilation on Aerosol Deposition: Imaging, Insight and Intervention

...................................................................................................................................................................................... 6 Acknowledgements ................................................................................................................................................................ 7 Introduction ................................................................................................................................................................ ............. 10 Chapter I: Analysis of Three Dimensional Aerosol Deposition in Pharmacologically Relevant Terms: Beyond Black or White ROIs ............................................................................................................................................. 16 Abstract ................................................................................................................................................................................. 17 Nomenclature ..................................................................................................................................................................... 18 Introduction ................................................................................................................................................................ ........ 20 Methods ................................................................................................................................................................................ 21 Results ................................................................................................................................................................ ................... 30 Discussion ............................................................................................................................................................................ 33 Acknowledgements .......................................................................................................................................................... 39 Author Disclosure Statement ....................................................................................................................................... 39 Appendixes ................................................................................................................................................................ .......... 39 Appendix I. Affine Transformation: ...................................................................................................................... 39 Appendix II. Volume Corrected Affine Parameterization: .......................................................................... 40 Appendix III. Airway Surface Area and Volume .............................................................................................. 41 Chapter II: What Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study ................................................................................................................................................................ ......... 43 Abstract ................................................................................................................................................................................. 44 Introduction ........................................................................................................................................................................ 45 Nomenclature ................................................................................................................................................................ ..... 46 Methods ................................................................................................................................................................ ................ 48 Theoretical Framework ............................................................................................................................................. 49 Experimental Methods............................................................................................................................................... 55 Results ................................................................................................................................................................................... 63 Discussion ................................................................................................................................................................ ............ 70 Acknowledgements .......................................................................................................................................................... 78 Author Disclosure Statement ....................................................................................................................................... 78 Appendix I ................................................................................................................................................................ ............ 79 Appendix II ................................................................................................................................................................ .......... 80